Yin Z Q, Li C Y, Pei X, Fang Q X
Shanghai Institute of Physiology, Chinese Academy of Sciences.
Invest Ophthalmol Vis Sci. 1994 Feb;35(2):626-34.
To follow the development of strabismic amblyopia longitudinally by comparing mean amplitudes and the visual spatial resolving ability of retinal and cortical pattern responses at various stages of postnatal development in unilateral iatrogenic convergent strabismic kittens.
Surgery to produce iatrogenic convergent strabismus was performed on 20 kittens at 3 weeks of age; three kittens were used for controls. The monocular transient pattern electroretinogram (PERG) and pattern visual evoked potential (PVEP) were recorded simultaneously on the 23 kittens throughout development.
The PVEPs of the strabismic eyes were very reduced at 4 to 5 postnatal weeks (P < 0.01). The reduction increased at 6 to 16 weeks but was even worse at 17 to 30 weeks. The PERG of the squinting eye showed only a slight reduction in the first 4 to 5 weeks of age (P > 0.05), the decrease of responses was significant (P < 0.01) at 6 to 16 weeks and 17 to 30 weeks. At 4 to 8 weeks of age, the PVEP evoked through the unoperated eye in kittens consisted mainly of two positive components of similar amplitude. During development, the slow component decreased in comparison to the fast one, and its peak shifted forward until it merged into the fast (P100) component.
Esotropic amblyopia did affect the PERG and the PVEP in the amblyopic eye, but the effect on the PERG was less severe, had slower onset, and did not continue as long as for the PVEP.
通过比较单侧医源性会聚性斜视小猫出生后不同发育阶段视网膜和皮质模式反应的平均振幅及视觉空间分辨能力，纵向追踪斜视性弱视的发展情况。
对20只3周龄的小猫进行手术以制造医源性会聚性斜视；3只小猫用作对照。在23只小猫的整个发育过程中同时记录单眼瞬态图形视网膜电图（PERG）和图形视觉诱发电位（PVEP）。
斜视眼的PVEP在出生后4至5周时显著降低（P<0.01）。在6至16周时降低加剧，但在17至30周时更严重。斜视眼的PERG在出生后的前4至5周仅略有降低（P>0.05），在6至16周和17至30周时反应降低显著（P<0.01）。在4至8周龄时，未手术眼诱发的小猫PVEP主要由两个振幅相似的正向成分组成。在发育过程中，慢成分与快成分相比减少，其峰值向前移动直至合并到快成分（P100）中。
内斜视性弱视确实影响弱视眼的PERG和PVEP，但对PERG的影响较轻，起病较慢，且持续时间不如对PVEP的影响长。
