Levinson R A, Paterson C A, Pfister R R
Invest Ophthalmol. 1976 Dec;15(12):986-93.
Depressed aqueous humor glucose and ascorbic acid levels returned to control values within 14 days following a 20 sec, 6 mm. diameter, 1N sodium hydroxide burn of the rabbit cornea. These corneas did not ulcerate or perforate. After a 20 sec., 12 mm. diameter, 1N sodium hydroxide burn, aqueous humor glucose levels returned to normal values, but ascorbic acid levels remained significantly depressed for up to 30 days. These corneas became markedly ulcerated in about 60 per cent of animals and frequently perforated. Following 12 mm. alkali burns, rabbits treated daily with 1.5 Gm. of subcutaneous ascorbic acid rarely developed corneal ulcerations and the corneas did not perforate. It is suggested that exogenous maintenance of adequate aqueous humor levels of ascorbic acid overcomes the relatively scorbutic state of the anterior segment induced by a 12 mm. alkali burn, thereby impairing the development of corneal ulceration and perforation. Elevated aqueous humor levels of ascorbic acid had no influence on corneal epithelial cell migration patterns following alkali burns.
兔角膜经20秒、直径6毫米、1N氢氧化钠烧灼后，房水葡萄糖和抗坏血酸水平降低，14天内恢复至对照值。这些角膜未发生溃疡或穿孔。经20秒、直径12毫米、1N氢氧化钠烧灼后，房水葡萄糖水平恢复正常，但抗坏血酸水平在长达30天内仍显著降低。约60%的动物角膜出现明显溃疡，且常发生穿孔。12毫米碱烧伤后，每天皮下注射1.5克抗坏血酸治疗的兔子很少发生角膜溃疡，角膜也未穿孔。提示外源性维持房水足够的抗坏血酸水平可克服12毫米碱烧伤诱导的眼前节相对坏血病状态，从而抑制角膜溃疡和穿孔的发生。碱烧伤后，房水抗坏血酸水平升高对角膜上皮细胞迁移模式无影响。
