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铁可用性对日本慢生根瘤菌hemA基因表达的影响。

Effect of iron availability on expression of the Bradyrhizobium japonicum hemA gene.

作者信息

Page K M, Connolly E L, Guerinot M L

机构信息

Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755.

出版信息

J Bacteriol. 1994 Mar;176(5):1535-8. doi: 10.1128/jb.176.5.1535-1538.1994.

DOI:10.1128/jb.176.5.1535-1538.1994
PMID:8113199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC205226/
Abstract

Bradyrhizobium japonicum produces delta-aminolevulinic acid, the universal precursor of tetrapyrroles, in a reaction catalyzed by the product of the hemA gene. Expression of the B. japonicum hemA gene is affected by iron availability. Activity of a hemA-lacZ fusion is increased approximately threefold by iron, and RNA analysis indicates that iron regulation is at the level of mRNA accumulation. To our knowledge, this is the first example of an iron-regulated heme biosynthetic gene in prokaryotes.

摘要

慢生根瘤菌通过hemA基因产物催化的反应产生δ-氨基乙酰丙酸，这是四吡咯的通用前体。慢生根瘤菌hemA基因的表达受铁供应的影响。铁可使hemA-lacZ融合体的活性增加约三倍，RNA分析表明铁调节作用发生在mRNA积累水平。据我们所知，这是原核生物中铁调节血红素生物合成基因的首个实例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af02/205226/90c9cbf21fbf/jbacter00023-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af02/205226/92d9254ada29/jbacter00023-0342-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af02/205226/90c9cbf21fbf/jbacter00023-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af02/205226/92d9254ada29/jbacter00023-0342-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af02/205226/90c9cbf21fbf/jbacter00023-0343-a.jpg

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本文引用的文献

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Bacterial delta-aminolevulinic acid synthase activity is not essential for leghemoglobin formation in the soybean/Bradyrhizobium japonicum symbiosis.在大豆/根瘤菌共生体中，细菌 δ-氨基乙酰丙酸合酶活性对于豆血红蛋白的形成不是必需的。
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Genetic Diversity in Bradyrhizobium japonicum Serogroup 123 and Its Relation to Genotype-Specific Nodulation of Soybean.大豆根瘤菌 123 血清群遗传多样性及其与基因型专化性结瘤的关系。
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J Bacteriol. 2001 Feb;183(4):1300-11. doi: 10.1128/JB.183.4.1300-1311.2001.
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J Bacteriol. 1997 Sep;179(17):5516-20. doi: 10.1128/jb.179.17.5516-5520.1997.
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The Bradyrhizobium japonicum fegA gene encodes an iron-regulated outer membrane protein with similarity to hydroxamate-type siderophore receptors.日本慢生根瘤菌的fegA基因编码一种铁调节外膜蛋白，与异羟肟酸型铁载体受体具有相似性。
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