6-硫鸟嘌呤治疗银屑病：81例患者的经验
6-Thioguanine treatment of psoriasis: experience in 81 patients.
作者信息
Zackheim H S, Glogau R G, Fisher D A, Maibach H I
机构信息
Department of Dermatology, University of California, San Francisco.
出版信息
J Am Acad Dermatol. 1994 Mar;30(3):452-8. doi: 10.1016/s0190-9622(94)70055-9.
BACKGROUND
Despite recent innovations a considerable number of patients with psoriasis cannot be successfully treated by current therapies.
OBJECTIVE
Our purpose was to summarize our 18-year experience with the antimetabolite 6-thioguanine in the management of patients with psoriasis.
METHODS
We retrospectively studied 81 patients who were treated with 6-thioguanine. A variety of schedules were used to find the optimal schedule. Forty-eight percent of the patients either had been treated with methotrexate or were excluded from receiving methotrexate because of liver or kidney disease.
RESULTS
Forty-nine percent of patients with plaques were effectively maintained with 6-thioguanine for a median of 33 months. Four of five patients with palmoplantar pustular psoriasis experienced substantial benefit. The most common side effect was myelosuppression.
CONCLUSION
6-Thioguanine is an effective therapy for psoriasis and should be considered for patients who have failed to respond to other systemic agents.
背景
尽管近期有创新疗法，但仍有相当数量的银屑病患者无法通过当前治疗得到成功治疗。
目的
我们的目的是总结我们在使用抗代谢物6-硫鸟嘌呤治疗银屑病患者方面18年的经验。
方法
我们回顾性研究了81例接受6-硫鸟嘌呤治疗的患者。采用了多种治疗方案以找到最佳方案。48%的患者曾接受过甲氨蝶呤治疗，或因肝脏或肾脏疾病而被排除接受甲氨蝶呤治疗。
结果
49%的斑块状银屑病患者使用6-硫鸟嘌呤有效维持，中位时间为33个月。五分之四的掌跖脓疱型银屑病患者获益显著。最常见的副作用是骨髓抑制。
结论
6-硫鸟嘌呤是治疗银屑病的有效疗法，对于对其他全身用药无反应的患者应予以考虑。
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