Rahman Hamidur, Hossain Md Rakib, Ferdous Tahmina
Department of Physics, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
Department of Physics, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh.
J Mol Liq. 2020 Dec 15;320:114427. doi: 10.1016/j.molliq.2020.114427. Epub 2020 Sep 30.
In this review article, we have presented a detailed analysis of the recent advancement of quantum mechanical calculations in the applications of the low-dimensional nanomaterials (LDNs) into biomedical fields like biosensors and drug delivery systems development. Biosensors play an essential role for many communities, e.g. law enforcing agencies to sense illicit drugs, medical communities to remove overdosed medications from the human and animal body etc. Besides, drug delivery systems are theoretically being proposed for many years and experimentally found to deliver the drug to the targeted sites by reducing the harmful side effects significantly. In current COVID-19 pandemic, biosensors can play significant roles, e.g. to remove experimental drugs during the human trials if they show any unwanted adverse effect etc. where the drug delivery systems can be potentially applied to reduce the side effects. But before proceeding to these noble and expensive translational research works, advanced theoretical calculations can provide the possible outcomes with considerable accuracy. Hence in this review article, we have analyzed how theoretical calculations can be used to investigate LDNs as potential biosensor devices or drug delivery systems. We have also made a very brief discussion on the properties of biosensors or drug delivery systems which should be investigated for the biomedical applications and how to calculate them theoretically. Finally, we have made a detailed analysis of a large number of recently published research works where theoretical calculations were used to propose different LDNs for bio-sensing and drug delivery applications.
在这篇综述文章中，我们详细分析了量子力学计算在低维纳米材料（LDNs）应用于生物传感器和药物递送系统开发等生物医学领域方面的最新进展。生物传感器对许多群体都起着至关重要的作用，例如执法机构用于检测非法药物，医疗群体用于从人体和动物体内清除过量药物等。此外，药物递送系统在理论上已被提出多年，并且通过显著降低有害副作用，实验发现其能够将药物递送至靶向部位。在当前的新冠疫情中，生物传感器可以发挥重要作用，例如在人体试验期间，如果实验药物显示出任何不良副作用，可将其清除等，而药物递送系统则可潜在地用于减少副作用。但在进行这些高尚且昂贵的转化研究工作之前，先进的理论计算能够以相当高的准确度提供可能的结果。因此，在这篇综述文章中，我们分析了如何利用理论计算来研究LDNs作为潜在的生物传感器装置或药物递送系统。我们还对生物传感器或药物递送系统的性质进行了非常简要的讨论，这些性质应针对生物医学应用进行研究以及如何从理论上进行计算。最后，我们对大量最近发表的研究工作进行了详细分析，这些研究工作利用理论计算提出了用于生物传感和药物递送应用的不同LDNs。
