β射线照射及随后涂抹4-硝基喹啉1-氧化物对小鼠皮肤肿瘤诱导的间隔效应。
Interval effect of beta-irradiation and subsequent 4-nitroquinoline 1-oxide painting on skin tumor induction in mice.
作者信息
Hoshino H, Tanooka H
出版信息
Cancer Res. 1975 Dec;35(12):3663-6.
PMID:811353
Abstract
Skin tumors were produced in female ICR mice by 90Sr-90Y beta-irradiation and subsequent 4-nitroquinoline 1-oxide painting. The doses were chosen so as to produce no tumors with a single agent alone; the interval between two treatments ranged from 11 to 408 days. The tumor induction rate was found to be at almost the same level (average, 12.4%) for each interval. The results indicate the persistence of the latent carcinogenic alterations in the beta-irradiated mouse skin.
摘要
通过用90Sr - 90Yβ射线照射并随后涂抹4 - 硝基喹啉1 - 氧化物，在雌性ICR小鼠身上诱发皮肤肿瘤。所选用的剂量使得单独使用任何一种试剂都不会诱发肿瘤；两次治疗之间的间隔时间为11至408天。发现每个间隔的肿瘤诱发率几乎处于同一水平（平均为12.4%）。结果表明β射线照射过的小鼠皮肤中存在潜在致癌改变的持续性。
相似文献
1
2
3
Zero tumor incidence in mice after repeated lifetime exposures to 0.5 Gy of beta radiation.小鼠在终生反复暴露于0.5戈瑞的β辐射后未出现肿瘤。
Radiat Res. 1993 May;134(2):244-6.
4
The tumor-initiating and -promoting effects of ionizing radiations in mouse skin.
Jpn J Cancer Res. 1987 Nov;78(11):1203-6.
5
Chronic exposure to ionizing radiation as a tumor promoter in mouse skin.长期暴露于电离辐射作为小鼠皮肤肿瘤促进剂。
Radiat Res. 1992 Feb;129(2):192-201.
6
Induction of osteosarcomas in mouse lumbar vertebrae by repeated external beta-irradiation.
Cancer Res. 1989 Mar 15;49(6):1562-4.
7
[Mammary tumor induction in rats by single and fractionated beta-irradiation with 90Sr-90Y].[用90Sr-90Y单次及分次β射线照射诱导大鼠乳腺肿瘤]
Radiobiologiia. 1983 Jan-Feb;23(1):54-8.
8
9
One hundred percent tumor induction in mouse skin after repeated beta irradiation in a limited dose range.在有限剂量范围内重复进行β射线照射后，小鼠皮肤的肿瘤诱发率达100%。
Radiat Res. 1988 Sep;115(3):488-94.
10
引用本文的文献
1
Investigating the impact of long term exposure to chemical agents on the chromosomal radiosensitivity using human lymphoblastoid GM1899A cells.研究长期暴露于化学制剂对人淋巴母细胞 GM1899A 细胞染色体辐射敏感性的影响。
Sci Rep. 2021 Jun 16;11(1):12616. doi: 10.1038/s41598-021-91957-y.
2
Effect of an inhibitor of tumor promotion, alpha-Difluoromethylornithine, on tumor induction by repeated beta irradiation in mice.肿瘤促进抑制剂α-二氟甲基鸟氨酸对小鼠反复β射线照射诱导肿瘤的影响。
Jpn J Cancer Res. 1993 Jan;84(1):34-6. doi: 10.1111/j.1349-7006.1993.tb02780.x.
Zotero 插件