Masuzawa M, Okuyama T, Kato M
Department of Gastroenterology, Osaka National Hospital.
Nihon Rinsho. 1994 Jan;52(1):203-8.
In liver cirrhosis, metabolic processes deteriorate, and serum amino acid imbalances may develop. Aromatic amino acids accumulate and branched-chain amino acids (BCAA) deficiencies develop, leading to hepatic encephalopathy and malnutrition. According to Fischer's reports, parenteral nutritional support with BCAA rich solution (Aminoleban (Otsuka), Morihepamin (Morishita)) is useful in patients with hepatic encephalopathy. Enteral nutritional support with BCAA rich solution (Aminoleban EN (Otsuka), Hepan-ED (Morishita)), together with low protein diet, may correct the specific metabolic abnormalities in patients with chronic hepatic failure and contribute to regain the quality of life and survival.
在肝硬化中,代谢过程恶化,血清氨基酸失衡可能会出现。芳香族氨基酸积累,支链氨基酸(BCAA)缺乏,导致肝性脑病和营养不良。根据菲舍尔的报告,用富含BCAA的溶液(大冢的Aminoleban、森下的Morihepamin)进行肠外营养支持对肝性脑病患者有用。用富含BCAA的溶液(大冢的Aminoleban EN、森下的Hepan-ED)进行肠内营养支持,同时采用低蛋白饮食,可能会纠正慢性肝衰竭患者的特定代谢异常,并有助于恢复生活质量和提高生存率。