Wang G J, Volkow N D, Fowler J S, Ferrieri R, Schlyer D J, Alexoff D, Pappas N, Lieberman J, King P, Warner D
Medical Department, Brookhaven National Laboratory, Upton, New York, 11973.
Life Sci. 1994;54(9):PL143-6. doi: 10.1016/0024-3205(94)00873-6.
To assess the effects of methylphenidate (MP) on cerebral blood flow (CBF), 5 healthy males were studied using 15O-water and positron emission tomography before and after MP (0.5 mg/kg iv). MP significantly decreased whole brain CBF at 5-10 minutes (25 +/- 11%) and at 30 minutes (20 +/- 10%) after its administration. Decrements in CBF were homogeneous throughout the brain (regional decrements 23-30%) and probably reflect the vasoactive properties of MP. The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.
为评估哌甲酯（MP）对脑血流量（CBF）的影响，在5名健康男性静脉注射MP（0.5mg/kg）前后，采用15O-水和正电子发射断层扫描对其进行了研究。给药后5 - 10分钟（25±11%）和30分钟（20±10%）时，MP显著降低全脑CBF。CBF的减少在全脑是均匀的（局部减少23 - 30%），这可能反映了MP的血管活性特性。长期使用该药和/或给有脑血管损害的患者使用时，应考虑MP的血管活性特性。
