Booij J, Korn P, Linszen D H, van Royen E A
Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Eur J Nucl Med. 1997 Jun;24(6):674-7. doi: 10.1007/BF00841408.
This double-blind, placebo-controlled study assessed pharmacologically induced endogenous dopamine (DA) release in healthy male volunteers (n=12). Changes in endogenous DA release after injection of the psychostimulant drug methylphenidate were evaluated by single-photon emission tomography (SPET) and constant infusion of iodine-123 iodobenzamide ([123I]IBZM), a D2 receptor radioligand that is sensitive to endogenous DA release. Methylphenidate induced displacement of striatal [123I]IBZM binding, resulting in a significantly decrease in the specific to non-specific [123I]IBZM uptake ratio (average: 8.6%) in comparison with placebo (average: -1.9%). Moreover, injection of methylphenidate induced significant behavioural responses on the following items: excitement, anxiety, tension, and mannerisms and posturing. The results of this study demonstrate the feasibility of using constant infusion of [123I]IBZM and SPET imaging to measure endogenous DA release after methylphenidate challenge and to investigate neurochemical aspects of behaviour.
这项双盲、安慰剂对照研究评估了健康男性志愿者（n = 12）体内药理学诱导的内源性多巴胺（DA）释放情况。通过单光子发射断层扫描（SPET）和持续输注碘-123 碘苄胺（[123I]IBZM，一种对内源性 DA 释放敏感的 D2 受体放射性配体），评估了注射精神兴奋药物哌醋甲酯后内源性 DA 释放的变化。哌醋甲酯引起纹状体[123I]IBZM 结合的置换，导致与安慰剂相比，特异性与非特异性[123I]IBZM 摄取率显著降低（平均：8.6%），而安慰剂组平均为-1.9%。此外，注射哌醋甲酯在以下项目上引起了显著的行为反应：兴奋、焦虑、紧张以及习性动作和姿势。本研究结果证明了使用持续输注[123I]IBZM 和 SPET 成像来测量哌醋甲酯激发后内源性 DA 释放以及研究行为的神经化学方面的可行性。
