Prout A J, Eisen A A
Neuromuscular Diseases Unit, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.
Muscle Nerve. 1994 Feb;17(2):217-23. doi: 10.1002/mus.880170213.
The cortical silent period (C-SP) was elicited by transcranial magnetic stimulation in 25 normal subjects and 19 patients with amyotrophic lateral sclerosis (ALS). The inhibitory (S-X) period was highly stimulus intensity (SI)-dependent (mean r2 = 0.89 for both normals and patients with ALS). The range of the C-SP (difference between maximum and minimum S-X intervals) was age-dependent for normals (r2 = 0.701, P < 0.001) but not patients with ALS. Means, maximums and ranges for the C-SP were not significantly different between normal and ALS groups and thresholds to cortical stimulation were also comparable. There was a significant, linear, relation between the maximum C-SP and disease duration of ALS (P = 0.002). The maximum C-SP was shorter early in the disease. It is hypothesized that the reduced inhibition early in the course of ALS might reflect glutamate-induced corticomotoneuronal excitotoxicity.
在25名正常受试者和19例肌萎缩侧索硬化症（ALS）患者中，通过经颅磁刺激诱发皮质静息期（C-SP）。抑制性（S-X）期高度依赖刺激强度（SI）（正常人和ALS患者的平均r2均为0.89）。正常受试者的C-SP范围（最大和最小S-X间期之差）与年龄有关（r2 = 0.701，P < 0.001），而ALS患者则不然。正常组和ALS组之间C-SP的均值、最大值和范围无显著差异，皮质刺激阈值也相当。ALS患者的最大C-SP与病程之间存在显著的线性关系（P = 0.002）。疾病早期最大C-SP较短。据推测，ALS病程早期抑制作用减弱可能反映了谷氨酸诱导的皮质运动神经元兴奋性毒性。
