Bouzas E A, Caruso R C, Drews-Bankiewicz M A, Kaiser-Kupfer M I
Ophthalmic Genetics and Clinical Services Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
Ophthalmology. 1994 Feb;101(2):309-14. doi: 10.1016/s0161-6420(13)31336-0.
To explore the abnormal crossing of the retinogeniculate pathways in human albinos with visual-evoked potentials (VEPs).
The authors studied the symmetry of the topographic distribution of pattern onset/offset VEPs over the posterior part of the scalp elicited by monocular stimulation of each eye in 31 consecutive patients with different types of albinism.
Twenty-one patients had asymmetric responses, with the major amplitude recorded over the lateral part of the scalp contralaterally to the stimulated eye in 14 patients and ipsilaterally in 7 patients. In two patients, the responses had a symmetric topographic distribution. In eight patients, the amplitude was so low that studying the symmetry was not possible.
These findings demonstrate a non-uniform pattern of asymmetry as a result of the miswiring of the visual pathways in human albinism. Moreover, the low amplitude of the VEP recorded in a consecutive series of patients shows the difficulty of the study of this phenomenon in a clinical setting.
利用视觉诱发电位（VEP）探究人类白化病患者视网膜膝状体通路的异常交叉。
作者研究了31例不同类型白化病患者在单眼刺激每只眼睛时，头皮后部模式起始/偏移VEP地形分布的对称性。
21例患者反应不对称，14例患者在受刺激眼对侧头皮外侧记录到主要振幅，7例患者在同侧记录到主要振幅。2例患者的反应具有对称的地形分布。8例患者的振幅过低，无法研究对称性。
这些发现表明，人类白化病患者视觉通路错接导致了不对称模式的不一致。此外，在一系列连续患者中记录到的VEP低振幅表明在临床环境中研究这一现象存在困难。
