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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Eison A S, Eison M S

CNS Drug Discovery, Bristol-Myers Squibb Company, Wallingford, CT.

Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jan;18(1):47-62. doi: 10.1016/0278-5846(94)90023-x.

Anatomical, behavioral, neurochemical and electrophysiological evidence collectively support a role for central 5-HT in the modulation of anxiety and the anti-anxiety action of the benzodiazepines. 2. The advent of selective agonists and antagonists for 5-HT receptor subtypes (5-HT1, 5-HT2, 5-HT3) has rekindled investigation of the role of 5-HT in anxiety mechanisms. 3. The azapirones represent a new class of agent which possesses affinity for 5-HT1A receptors (partial agonists) and is active in anxiolytic animal models as well as in the clinic (buspirone) 4. While preclinical data supporting the anxiolytic potential of 5-HT2 antagonists remains controversial, a recent clinical study supports ritanserin's anxiolytic effects. 5. Several animal models support the anxiolytic potential of the 5-HT3 antagonist odansetron (GR38032F). Confirmation of it's therapeutic utility awaits clinical results.

解剖学、行为学、神经化学和电生理学证据共同支持中枢5-羟色胺（5-HT）在调节焦虑及苯二氮䓬类抗焦虑作用中的作用。2. 5-羟色胺受体亚型（5-HT1、5-HT2、5-HT3）选择性激动剂和拮抗剂的出现重新激发了对5-羟色胺在焦虑机制中作用的研究。3. 氮杂螺酮代表一类新型药物，它对5-HT1A受体具有亲和力（部分激动剂），在抗焦虑动物模型及临床中（丁螺环酮）均有活性。4. 虽然支持5-HT2拮抗剂抗焦虑潜力的临床前数据仍存在争议，但最近一项临床研究支持了利坦色林的抗焦虑作用。5. 几种动物模型支持5-HT3拮抗剂奥丹西隆（GR38032F）的抗焦虑潜力。其治疗效用的确认有待临床结果。

Eison A S, Eison M S

CNS Drug Discovery, Bristol-Myers Squibb Company, Wallingford, CT.

Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jan;18(1):47-62. doi: 10.1016/0278-5846(94)90023-x.

Anatomical, behavioral, neurochemical and electrophysiological evidence collectively support a role for central 5-HT in the modulation of anxiety and the anti-anxiety action of the benzodiazepines. 2. The advent of selective agonists and antagonists for 5-HT receptor subtypes (5-HT1, 5-HT2, 5-HT3) has rekindled investigation of the role of 5-HT in anxiety mechanisms. 3. The azapirones represent a new class of agent which possesses affinity for 5-HT1A receptors (partial agonists) and is active in anxiolytic animal models as well as in the clinic (buspirone) 4. While preclinical data supporting the anxiolytic potential of 5-HT2 antagonists remains controversial, a recent clinical study supports ritanserin's anxiolytic effects. 5. Several animal models support the anxiolytic potential of the 5-HT3 antagonist odansetron (GR38032F). Confirmation of it's therapeutic utility awaits clinical results.

解剖学、行为学、神经化学和电生理学证据共同支持中枢5-羟色胺（5-HT）在调节焦虑及苯二氮䓬类抗焦虑作用中的作用。2. 5-羟色胺受体亚型（5-HT1、5-HT2、5-HT3）选择性激动剂和拮抗剂的出现重新激发了对5-羟色胺在焦虑机制中作用的研究。3. 氮杂螺酮代表一类新型药物，它对5-HT1A受体具有亲和力（部分激动剂），在抗焦虑动物模型及临床中（丁螺环酮）均有活性。4. 虽然支持5-HT2拮抗剂抗焦虑潜力的临床前数据仍存在争议，但最近一项临床研究支持了利坦色林的抗焦虑作用。5. 几种动物模型支持5-HT3拮抗剂奥丹西隆（GR38032F）的抗焦虑潜力。其治疗效用的确认有待临床结果。