克氏锥虫与实验性恰加斯病：从一名伴有消化和心脏型症状的患者分离出的毒株的特征

Trypanosoma cruzi and experimental Chagas' disease: characterization of a stock isolated from a patient with associated digestive and cardiac form.

作者信息

Oliveira E C, Stefani M M, Luquetti A O, Vêncio E F, Moreira M A, Souza C, Rezende J M

机构信息

Departamento de Parasitologia, Faculdade de Medicina/Universidade Federal de Goiás, Goiânia.

出版信息

Rev Soc Bras Med Trop. 1993 Jan-Mar;26(1):25-33. doi: 10.1590/s0037-86821993000100006.

DOI:10.1590/s0037-86821993000100006

PMID:8115685

Abstract

A new Trypanosoma cruzi stock isolated from a patient in the chronic phase of Chagas' disease with the digestive and cardiac form of the disease was characterized by experimental infection in isogenic, susceptible, A/Sn strain mice. Parasitemia curves showed up to 1.7 x 10(6) parasites/ml and no mortality was observed up to 300 days post infection. Specific IgM was found in mice in the acute phase up to 40 days and also in the chronic phase. IgG antibodies were detected in the acute and chronic phase. Histopathology examination demonstrated myotropism to the digestive tract muscle layers and to the heart.

摘要

从一名患有查加斯病慢性期且伴有消化系统和心脏型疾病的患者身上分离出的一种新型克氏锥虫毒株，通过在同基因、易感的A/Sn品系小鼠中进行实验性感染来进行特征描述。寄生虫血症曲线显示每毫升高达1.7×10⁶个寄生虫，感染后300天内未观察到死亡情况。在急性期长达40天以及慢性期的小鼠体内均发现了特异性IgM。在急性期和慢性期均检测到了IgG抗体。组织病理学检查表明该毒株对消化道肌肉层和心脏具有嗜肌性。