de Almeida-Ribeiro R, Lourenço D M, Dias J C, Shikanai-Yasuda M A, Chapadeiro E, Lopes E R
Departamento de Doenças Infecciosas e Parasitárias da Faculdade de Medicina da Universidade de São Paulo, Brasilia, Uberaba, MG, Brasil.
Rev Soc Bras Med Trop. 1993 Jan-Mar;26(1):35-8. doi: 10.1590/s0037-86821993000100007.
An analysis of the intracardiac autonomic nervous system (ICANS) has been made in 150 histological sections obtained from atrial fragments of a 74 year-old man who died of cardiac failure, as a consequence of acute Chagas' disease (ACD), probably acquired via digestive tract. Small quantities of mononuclear infiltrate around ganglia and/or nerve branches without significant morphologic alterations of the neurons were found in 10 slides; another slide showed ganglionitis and periganglionitis of moderate intensity associated to neuronal alterations. Focal epicarditis, usually of slight degree, was observed in all slides. The findings suggest: a) that the inflammation of ganglia and fibers of the ICANS in the ACD occurs at least in part by expansion from adjacent epicarditis; b) that even in the fatal cases of the trypanosomiasis cruzi the pathologic lesions of the ICANS may be slight.
对一名74岁男性的心脏自主神经系统（ICANS）进行了分析，该男性因急性恰加斯病（ACD）死于心力衰竭，可能是通过消化道感染的。从其心房碎片获取的150个组织学切片中，10张切片发现神经节和/或神经分支周围有少量单核浸润，神经元无明显形态学改变；另一张切片显示中度强度的神经节炎和神经节周炎，并伴有神经元改变。在所有切片中均观察到局灶性心外膜炎，通常程度较轻。这些发现表明：a）急性恰加斯病中心脏自主神经系统神经节和纤维的炎症至少部分是由相邻的心外膜炎扩展引起的；b）即使在克氏锥虫病的致命病例中，心脏自主神经系统的病理损害也可能很轻微。
