de Souza M M, Andrade S G, Barbosa A A, Macedo Santos R T, Alves V A, Andrade Z A
Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz, FIOCRUZ, Salvador, BA, Brasil.
Mem Inst Oswaldo Cruz. 1996 Mar-Apr;91(2):217-24. doi: 10.1590/s0074-02761996000200018.
Lesions involving the sympathetic (para-vertebral ganglia) and para-sympathetic ganglia of intestines (Auerbach plexus) and heart (right atrial ganglia) were comparatively analyzed in mice infected with either of three different strain types of Trypanosoma cruzi, during acute and chronic infection, in an attempt to understand the influence of parasite strain in causing autonomic nervous system pathology. Ganglionar involvement with neuronal destruction appeared related to inflammation, which most of the times extended from neighboring adipose and cardiac, smooth and striated muscular tissues. Intraganglionic parasitism was exceptional. Inflammation involving peripheral nervous tissue exhibited a focal character and its variability in the several groups examined appeared unpredictable. Although lesions were generally more severe with the Y strain, comparative qualitative study did not allow the conclusion, under the present experimental conditions, that one strain was more pathogenic to the autonomic nervous system than others. No special tropism of the parasites from any strain toward autonomic ganglia was disclosed.
对感染三种不同菌株类型克氏锥虫的小鼠在急性和慢性感染期间，其交感神经（椎旁神经节）以及肠道（奥尔巴赫神经丛）和心脏（右心房神经节）的副交感神经节病变进行了比较分析，以试图了解寄生虫菌株在导致自主神经系统病理学方面的影响。神经节受累及神经元破坏似乎与炎症有关，炎症大多时候从邻近的脂肪组织、心脏、平滑肌和横纹肌组织蔓延而来。神经节内寄生情况较为罕见。累及外周神经组织的炎症表现为局灶性，在所检查的几组中其变异性似乎无法预测。尽管Y菌株导致的病变通常更严重，但在当前实验条件下，比较性定性研究无法得出一种菌株比其他菌株对自主神经系统更具致病性的结论。未发现任何菌株的寄生虫对自主神经节有特殊嗜性。
