Xiang Z Q, Spitalnik S, Tran M, Wunner W H, Cheng J, Ertl H C
Wistar Institute, Philadelphia, Pennsylvania 19104.
Virology. 1994 Feb 15;199(1):132-40. doi: 10.1006/viro.1994.1105.
A plasmid vector, termed pSG5rab.gp, that expresses the rabies virus glycoprotein under the control of an SV40 early promoter, was tested in C3H/He mice for induction of rabies virus-specific immune responses. Mice immunized intramuscularly with the pSG5rab.gp vector developed rabies virus glycoprotein-specific cytolytic T cells, lymphokine-secreting T helper cells of the TH1 subset, and rabies virus-neutralizing antibodies. Mice vaccinated with the pSG5rab.gp vector were fully protected against a subsequent challenge with rabies virus.
一种名为pSG5rab.gp的质粒载体，在SV40早期启动子的控制下表达狂犬病病毒糖蛋白，在C3H/He小鼠中进行了测试，以诱导狂犬病病毒特异性免疫反应。用pSG5rab.gp载体进行肌肉注射免疫的小鼠产生了狂犬病病毒糖蛋白特异性细胞溶解T细胞、分泌淋巴因子的TH1亚群辅助性T细胞以及狂犬病病毒中和抗体。用pSG5rab.gp载体接种疫苗的小鼠对随后的狂犬病病毒攻击具有完全的保护作用。
