Aichberger C, Lechner W, Ofner D, Pernthaler H, Königsrainer A, Margreiter R
Abteilung für Transplantationschirurgie, I. Universitätsklinik für Chirurgie, Innsbruck.
Wien Klin Wochenschr. 1993;105(24):723-7.
11 women gave birth to 13 live-born infants after a mean period of 39.6 months following transplantation, whereby one of these women had two successful pregnancies and one patient had a twin pregnancy. The highly premature twins, born after a complicated pregnancy with impaired renal graft function in the mother, died of respiratory insufficiency on the 13th day. All of these renal allograft recipients had to be delivered by caesarean section, either for nephrological or obstetric reasons. All graft with stable function prior to conception suffered no damage as a result of the pregnancy. In two women with already impaired function, pregnancy led to further deterioration and, eventually, graft loss. Because of the small numbers in this series no conclusions can be drawn with regard to the incidence of malformation of premature delivery. It is concluded that women with normal and stable renal graft function should be allowed to become pregnant. The risk for the graft as well as for the child does not seem to be increased under these circumstances. However, due to the complexity of the situation these patients should be cared for at specialized centres.
11名女性在移植后平均39.6个月产下13名活产婴儿,其中一名女性成功怀孕两次,一名患者怀有双胞胎。这对极度早产的双胞胎在母亲肾移植功能受损的复杂妊娠后出生,于第13天死于呼吸功能不全。所有这些肾移植受者均因肾病或产科原因不得不通过剖宫产分娩。所有在受孕前功能稳定的移植物均未因妊娠而受损。在两名功能已受损的女性中,妊娠导致功能进一步恶化,最终移植物丧失。由于本系列病例数量较少,无法就早产畸形的发生率得出结论。得出的结论是,肾移植功能正常且稳定的女性应该被允许怀孕。在这种情况下,移植物和胎儿的风险似乎并未增加。然而,由于情况复杂,这些患者应在专科中心接受护理。