多发性硬化症中的顽固性呃逆和睡眠呼吸暂停综合征：两例报告。

Intractable hiccups and sleep apnea syndrome in multiple sclerosis: report of two cases.

作者信息

Funakawa I, Hara K, Yasuda T, Terao A

机构信息

Department of Internal Medicine, Kawasaki Medical School, Japan.

出版信息

Acta Neurol Scand. 1993 Dec;88(6):401-5. doi: 10.1111/j.1600-0404.1993.tb05367.x.

DOI:10.1111/j.1600-0404.1993.tb05367.x

PMID:8116339

Abstract

Two cases of multiple sclerosis associated with intractable hiccups (IH) and sleep apnea syndrome (SAS) are reported. Lesions were detected in the tegmentum of the medulla oblongata by magnetic resonance imaging. In one case, high dose methylprednisolone was remarkably effective for the IH. For the SAS, amitriptyline was effective in one case. The IH and SAS are thought to be important symptoms when a lesion occurs in the tegmentum of the medulla oblongata, including the paramedian and lateral reticular formations. If IH appears in conjunction with a lesion in the tegmentum of the medulla oblongata, one must be vigilant for the development of SAS.

摘要

报告了两例多发性硬化症合并顽固性呃逆（IH）和睡眠呼吸暂停综合征（SAS）的病例。通过磁共振成像在延髓被盖部检测到病变。在一例中，大剂量甲基强的松龙对呃逆有显著疗效。对于睡眠呼吸暂停综合征，阿米替林在一例中有效。当延髓被盖部发生病变，包括内侧纵束旁和外侧网状结构时，呃逆和睡眠呼吸暂停综合征被认为是重要症状。如果呃逆与延髓被盖部病变同时出现，必须警惕睡眠呼吸暂停综合征的发生。