McFarling D A, Susac J O
Neurology. 1979 Jun;29(6):797-801. doi: 10.1212/wnl.29.6.797.
In three patients, intractable hiccups occurred as part of the symptomatology of multiple sclerosis. In one patient intractable hiccups were the presenting complaint, and in another patient exacerbations of symptoms were almost always heralded by intractable hiccups. Intractable hiccups occur in a variety of diseases, including many that affect the brainstem and cervical cord, but have not been reported in multiple sclerosis. The hiccup may be a "primitive" gastrointestinal reflex that is disinhibited by lesions such as multiple sclerosis plaques. Carbamazepine was successful in arresting the hiccups in one of the cases presented.
在三名患者中，顽固性呃逆作为多发性硬化症症状学的一部分出现。在一名患者中，顽固性呃逆是首发症状，而在另一名患者中，症状加重几乎总是由顽固性呃逆预示。顽固性呃逆发生于多种疾病，包括许多影响脑干和颈髓的疾病，但在多发性硬化症中尚未见报道。呃逆可能是一种“原始”的胃肠反射，被诸如多发性硬化斑块之类的病变解除抑制。在其中一例报道中，卡马西平成功止住了呃逆。
