Franklin R J, Blakemore W F
MRC Cambridge Centre for Brain Repair, Department of Clinical Veterinary Medicine, University of Cambridge, U.K.
Int J Dev Neurosci. 1993 Oct;11(5):641-9. doi: 10.1016/0736-5748(93)90052-f.
Schwann cells are able to migrate into the CNS and myelinate CNS axons in a number of developmental and pathological situations. Morphological studies based on normal, mutant and experimentally-lesioned tissue have indicated that Schwann cells are only able to enter the CNS when the integrity of the astrocytic glia limitans is disrupted. The significance and subtlety of the interactions between Schwann cells and astrocytes have been further explored by glial cell transplantation studies. These studies support in vitro observations on Schwann cell behaviour in highlighting the importance of extracellular matrix for both migration and myelin sheath formation. The failure of Schwann cells to intermix with astrocytes is an important aspect of glial cell biology which will have a bearing on efforts to remyelinate demyelinated axons by Schwann cell-transplantation.
在许多发育和病理情况下,施万细胞能够迁移到中枢神经系统并使中枢神经系统轴突形成髓鞘。基于正常、突变和实验性损伤组织的形态学研究表明,只有当星形胶质细胞界膜的完整性被破坏时,施万细胞才能进入中枢神经系统。通过胶质细胞移植研究进一步探索了施万细胞与星形胶质细胞之间相互作用的意义和微妙之处。这些研究支持了关于施万细胞行为的体外观察,突出了细胞外基质对迁移和髓鞘形成的重要性。施万细胞无法与星形胶质细胞混合是胶质细胞生物学的一个重要方面,这将影响通过施万细胞移植使脱髓鞘轴突重新髓鞘化的努力。