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用于治疗马四肢远端全层切除性伤口的封闭敷料评估。

Evaluation of occlusive dressings for management of full-thickness excisional wounds on the distal portion of the limbs of horses.

作者信息

Howard R D, Stashak T S, Baxter G M

机构信息

Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.

出版信息

Am J Vet Res. 1993 Dec;54(12):2150-4.

PMID:8116952
Abstract

Two 2.5-cm2 full-thickness skin wounds were created surgically over the lateral aspect of the cannon bone of each limb of 6 horses (n = 48 wounds). Dressings evaluated were a nonadherent gauze pad (group 1); a synthetic semiocclusive dressing, (group 2); equine amnion (group 3); and a synthetic fully occlusive dressing (group 4). Wounds were assessed subjectively at each dressing change, and total wound area, area of granulation tissue, and area of epithelium in each wound were determined by computerized digital analysis of photographs of the wounds. Complete healing time (wound covered by epithelium) also was determined for each wound. Statistical comparisons were made, using Kruskal-Wallis analysis and a Mann-Whitney U test. Median time to complete healing was: group 1, 53 days; group 2, 71 days; group 3, 63 days; and group 4, 113 days. Time to complete healing was significantly longer for wounds of group-4 horses than all other groups, and wounds of group-1 horses healed faster than did those of group-2 horses (P < 0.05). Wounds in group-4 horses required significantly (P < or = 0.05) more excisions of granulation tissue (median, 11.5 times) than did those in group-1 (median, 3.5), group-2 (median, 5.5) or group-3 (median, 2.5) horses. Epithelial tissue was detected later in wounds of group-4 horses (median, 27 days) than in wounds of horses in groups 1, 2 or 3 (median, 17 days); however, this difference was not statistically significant.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

在6匹马的每只肢体的管骨外侧通过手术制造两个2.5平方厘米的全层皮肤伤口(n = 48个伤口)。评估的敷料有:非粘性纱布垫(第1组);合成半封闭敷料(第2组);马羊膜(第3组);合成全封闭敷料(第4组)。每次更换敷料时对伤口进行主观评估,并通过对伤口照片进行计算机数字分析来确定每个伤口的总伤口面积、肉芽组织面积和上皮面积。还确定了每个伤口的完全愈合时间(伤口被上皮覆盖)。使用Kruskal-Wallis分析和Mann-Whitney U检验进行统计比较。完全愈合的中位时间为:第1组53天;第2组71天;第3组63天;第4组113天。第4组马的伤口完全愈合时间明显长于所有其他组,第1组马的伤口愈合速度比第2组马快(P < 0.05)。第4组马的伤口比第1组(中位值3.5次)、第2组(中位值5.5次)或第3组(中位值2.5次)马的伤口需要更多次切除肉芽组织(中位值11.5次)(P≤0.05)。第4组马的伤口中上皮组织出现的时间(中位值27天)比第1、2或3组马的伤口(中位值17天)晚;然而,这种差异无统计学意义。(摘要截断于250字)

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