[阿尔及尔阿尔及利亚人的HLA - DRB1和HLA - DQB1基因多态性]

[HLA-DRB1 and HLA-DQB1 polymorphism in Algerians from Algiers].

作者信息

Reviron D, André M, Cantaloube J F, Biagini P, Chicheportiche C, Mercier P

机构信息

Centre Régional de Transfusion Sanguine de Marseille.

出版信息

Rev Fr Transfus Hemobiol. 1993 Dec;36(6):509-16. doi: 10.1016/s1140-4639(05)80225-4.

DOI:10.1016/s1140-4639(05)80225-4

PMID:8117375

Abstract

The polymorphism of HLA-DRB1 and HLA-DQB1 genes in 100 unrelated Algerians from Alger was investigated using PCR amplification and oligonucleotide typing. Compared to western Europeans, this population shows a higher haplotypic frequency of HLA DRB103-DQB10201 (21.5%) and a lower haplotypic frequency of DRB10101-DQB10501 (2%). Two unexpected haplotypes are observed: DRB107-DQB10301 and DRB10406-DQB10402. DRB10402 is the most common subtype in the DRB104 group. Furthermore, we detected a rare DQB1*0305 allele, only found in a Sardinian subject until today.

摘要

利用聚合酶链反应（PCR）扩增和寡核苷酸分型技术，对来自阿尔及尔的100名无亲缘关系的阿尔及利亚人HLA - DRB1和HLA - DQB1基因的多态性进行了研究。与西欧人相比，该人群中HLA DRB103 - DQB10201单倍型频率较高（21.5%），而DRB10101 - DQB10501单倍型频率较低（2%）。观察到两种意外的单倍型：DRB107 - DQB10301和DRB10406 - DQB10402。DRB10402是DRB104组中最常见的亚型。此外，我们检测到一个罕见的DQB1*0305等位基因，迄今为止仅在一名撒丁岛受试者中发现。