Soerensen J B, Smith D F
Department of Organic Chemistry, University of Aarhus, Denmark.
J Neural Transm Park Dis Dement Sect. 1993;6(2):139-44. doi: 10.1007/BF02261007.
Learning of rats given either piracetam, 2-thio-1-pyrrolidine-acetamide (thioacet) or 2-thio-1-pyrrolidine-thio-acetamide (thiothio) was studied in order to investigate nootropic effects of the compounds. Learning ability was measured using a Y-maze with water reward for the correct choice in a black-white discrimination task. Thioacet and thiothio enhanced learning ability of the rats at doses that were 2.5-10 times lower than those required for obtaining nootropic effects of piracetam. Thus the thio-derivatives of piracetam might be of value for studying mechanisms of action of nootropic drugs.
为了研究这些化合物的益智作用，对给予吡拉西坦、2-硫代-1-吡咯烷乙酰胺（硫代乙酰胺）或2-硫代-1-吡咯烷硫代乙酰胺（二硫代乙酰胺）的大鼠的学习情况进行了研究。在黑白辨别任务中，使用带有水奖励的Y型迷宫来测量正确选择时的学习能力。硫代乙酰胺和二硫代乙酰胺在比获得吡拉西坦益智作用所需剂量低2.5至10倍的剂量下增强了大鼠的学习能力。因此，吡拉西坦的硫代衍生物可能对研究益智药物的作用机制有价值。
