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[学校人群中的麻疹疫情。疫苗的有效性]

[Measles epidemic in a school population. Effectiveness of the vaccine].

作者信息

Cosín Borobio R

机构信息

Centro de Salud de San Leonardo de Yagüe, Soria.

出版信息

Aten Primaria. 1993 Dec;12(10):676-8.

PMID:8117889
Abstract

OBJECTIVE

To describe the distribution of the illness according to the school students' measles vaccination status and to assess its effectiveness.

DESIGN

Analytical study of a retrospective cohort.

SETTING

Two schools within the Base Health Area of San Leonardo de Yagüe, Soria.

PATIENTS

410 school students between 3 and 14. 314 were included in the study sample.

MEASUREMENTS AND MAIN RESULTS

The overall vaccination rate was 81.8% and was higher among lower age groups. The overall incidence rate was 18.5%; 9.7% in those vaccinated and 57.9% in those not vaccinated. The incidence rates increased with age, 5.5% for the 3-6 and 24.5% for the 11-14 age groups. Vaccine effectiveness was measured by Relative Risk (5.9) and Attributable Fraction (83.2%), with a statistically significant association between non-vaccination and the occurrence of measles.

CONCLUSIONS

As measles vaccination is highly effective, it would be worthwhile to increase vaccine coverage to 93.5-96%, so that group immunity within a community can be attained and so transmission of the disease be avoided.

摘要

目的

根据在校学生的麻疹疫苗接种状况描述疾病分布情况,并评估其有效性。

设计

回顾性队列分析研究。

地点

索里亚省圣莱昂纳多·德亚圭基础卫生区的两所学校。

研究对象

410名3至14岁的在校学生。研究样本纳入314名学生。

测量指标及主要结果

总体疫苗接种率为81.8%,在较低年龄组中更高。总体发病率为18.5%;接种疫苗者为9.7%,未接种疫苗者为57.9%。发病率随年龄增长而升高,3至6岁年龄组为5.5%,11至14岁年龄组为24.5%。通过相对危险度(5.9)和归因分数(83.2%)衡量疫苗有效性,未接种疫苗与麻疹发病之间存在统计学显著关联。

结论

由于麻疹疫苗非常有效,将疫苗接种覆盖率提高到93.5% - 96%是值得的,这样可以实现社区内的群体免疫,从而避免疾病传播。

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