Astashkin E I, Khodorova A B, Tumanova O A, Samoĭlova V E, Dukhanin A S
Biull Eksp Biol Med. 1993 Oct;116(10):400-2.
Arachidonic acid (1-3 microM) induces a rapid dose-dependent rise of free Ca2+ contents [Ca2+]i in the cytoplasm of JW cells. An increase of [Ca2+]i is the consequence of Ca2+ influx and Ca2+ efflux from intracellular calcium sources. Hydrocortisone (0.5-5 microM) blocks plasma membrane Ca2+ channels and inhibits arachidonic acid-stimulated Ca(2+) influx in JW cells. The presented data suggest that arachidonic acid and hydrocortisone have membranotropic activity on plasmacytoma JW cells.
花生四烯酸(1 - 3微摩尔)可使JW细胞胞质内的游离钙离子含量[Ca2+]i迅速呈剂量依赖性升高。[Ca2+]i的增加是细胞外钙离子内流和细胞内钙源释放钙离子外流的结果。氢化可的松(0.5 - 5微摩尔)可阻断质膜钙离子通道,并抑制花生四烯酸刺激的JW细胞钙离子内流。所呈现的数据表明,花生四烯酸和氢化可的松对浆细胞瘤JW细胞具有膜otropic活性。 (注:原文中“membranotropic”这个词可能有误,推测可能是“membraneotropic”,但按照要求未做修改直接翻译)