Rashed M Z, Sharawy M M
Department of Oral Biology/Anatomy, School of Dentistry, Medical College of Georgia, Augusta 30912.
Cranio. 1993 Oct;11(4):291-6; discussion 297. doi: 10.1080/08869634.1993.11677981.
The objective of this study was to evaluate the effect of raising the vertical dimension of occlusion on the condylar cartilage of young adult rabbits. Ten rabbits of approximately the same age were divided into two equal control and experimental groups. The vertical dimension of occlusion of the experimental group was raised bilaterally 1.5 mm using composite resin. No procedure was done for the control group. Animals were sacrificed during a six week period, and changes in condylar cartilage of experimental animals (compared to controls) were evaluated histomorphometrically. In addition, alterations of collagen type I and II were detected using immunohistochemical techniques. The results demonstrated an increase in the volume of the experimental condylar cartilage, which was attributed to an increase in the cartilage zone. Immunohistochemical examination of the hyperplastic cartilage showed no evidence for the production of type I collagen. These changes in condylar cartilage were considered adaptive and may lead to change in condylar shape. Further studies are needed to show if these adaptive changes would progress into osteoarthritis.
本研究的目的是评估增加咬合垂直距离对成年幼兔髁突软骨的影响。将十只年龄大致相同的兔子分为两个相等的对照组和实验组。实验组通过复合树脂双侧增加咬合垂直距离1.5毫米。对照组未进行任何操作。在六周内处死动物，并通过组织形态计量学评估实验动物（与对照组相比）髁突软骨的变化。此外，使用免疫组织化学技术检测I型和II型胶原蛋白的改变。结果表明，实验性髁突软骨体积增加，这归因于软骨区域的增加。对增生软骨的免疫组织化学检查未发现I型胶原蛋白产生的证据。髁突软骨的这些变化被认为是适应性的，可能导致髁突形状改变。需要进一步研究以表明这些适应性变化是否会发展为骨关节炎。
