Tabsh K, Nuwayhid B, Erkkola R, Zugaib M, Lieb S, Ushioda E, Brinkman C R, Assali N S
Biol Neonate. 1981;39(1-2):52-60. doi: 10.1159/000241392.
The responses of the common internal iliac artery and middle uterine artery of the pregnant horn to continuous infusions of graded doses of norepinephrine, epinephrine, dopamine, isoxsuprine, angiotensin and nitroprusside were investigated in chronically instrumental pregnant ewes. Norepinephrine progressively decreased the blood flow and increased the resistance in both vessels but the changes were more marked in the middle uterine artery. Isoxsuprine and epinephrine had an insignificant effect on the common internal iliac artery blood flow, but decreased that of the middle uterine artery. Nitroprusside decrease the flow in both vessels proportionately. Angiotensin in doses less than 0.16 micrograms/kg/min increased the flow in both arteries to the same extent, but higher doses decreased both flows. It is concluded that in the chronically instrumented pregnant ewe, the responses of contiguous vascular beds to different vasoactive agents may differ depending on the nature of the stimulus.
在长期植入仪器的妊娠母羊中，研究了妊娠侧角的髂内动脉和子宫中动脉对不同剂量去甲肾上腺素、肾上腺素、多巴胺、异舒普林、血管紧张素和硝普钠持续输注的反应。去甲肾上腺素使两条血管的血流量逐渐减少，阻力增加，但子宫中动脉的变化更明显。异舒普林和肾上腺素对髂内动脉血流量影响不显著，但使子宫中动脉血流量减少。硝普钠使两条血管的血流量成比例减少。剂量小于0.16微克/千克/分钟的血管紧张素使两条动脉的血流量增加程度相同，但更高剂量则使血流量均减少。结论是，在长期植入仪器的妊娠母羊中，相邻血管床对不同血管活性药物的反应可能因刺激的性质而异。
