Weynants P, Lethé B, Brasseur F, Marchand M, Boon T
Ludwig Institute for Cancer Research, Brussels Branch, Belgium.
Int J Cancer. 1994 Mar 15;56(6):826-9. doi: 10.1002/ijc.2910560612.
Human gene MAGE-I codes for an antigen that is recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). This antigen is potentially useful as a target for cancer immunotherapy because gene MAGE-I is not expressed in any normal tissues except the testis. We tested 46 surgical samples of non-small-cell lung carcinomas and observed MAGE-I expression in 16 of them (35%). Genes MAGE-2 and 3, which are closely related to MAGE-I, were expressed by a similar proportion of these tumors. Some small-cell lung tumors also express MAGE genes. The proportion of tumors expressing MAGE-I suggests that lung tumor patients may constitute the largest group of patients potentially eligible for pilot studies involving MAGE-I immunization.
人类基因MAGE-I编码一种抗原，该抗原可被自体溶细胞性T淋巴细胞（CTL）识别，存在于黑色素瘤细胞上。这种抗原有可能作为癌症免疫治疗的靶点，因为除了睾丸外，基因MAGE-I在任何正常组织中都不表达。我们检测了46份非小细胞肺癌手术样本，其中16份（35%）检测到MAGE-I表达。与MAGE-I密切相关的基因MAGE-2和MAGE-3在这些肿瘤中的表达比例相似。一些小细胞肺癌肿瘤也表达MAGE基因。表达MAGE-I的肿瘤比例表明，肺癌患者可能构成了有资格参与涉及MAGE-I免疫接种的初步研究的最大患者群体。
