Patard J J, Brasseur F, Gil-Diez S, Radvanyi F, Marchand M, François P, Abi-Aad A, Van Cangh P, Abbou C C, Chopin D
Ludwig Institute for Cancer Research, Brussels, Belgium.
Int J Cancer. 1995 Feb 20;64(1):60-4. doi: 10.1002/ijc.2910640112.
Human genes MAGE-1 and MAGE-3 code for distinct antigens, which are recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). These antigens may constitute useful targets for anti-cancer immunotherapy, since no expression of MAGE genes has been observed in normal tissues other than testis. Out of 57 samples of primary transitional-cell carcinomas of the bladder, 12 (21%) expressed MAGE-1 and 20 (35%) expressed MAGE-3. All but one of the tumors expressing MAGE-1 also expressed MAGE-3. Genes MAGE-2 and MAGE-4, which are closely related to MAGE-1 and MAGE-3, were expressed by 30% and 33% of the tumors respectively. MAGE expression was more frequent in advanced tumor stages: 61% of the invasive tumors (stage > or = T2) were positive for expression of at least one of the four genes, whereas only 28% of the superficial tumors (stages Ta and T1) expressed these genes.
人类基因MAGE-1和MAGE-3编码不同的抗原，这些抗原可被自体溶细胞性T淋巴细胞（CTL）识别为黑色素瘤细胞上的抗原。这些抗原可能构成抗癌免疫疗法的有用靶点，因为除睾丸外，在正常组织中未观察到MAGE基因的表达。在57例原发性膀胱移行细胞癌样本中，12例（21%）表达MAGE-1，20例（35%）表达MAGE-3。除1例肿瘤外，所有表达MAGE-1的肿瘤也表达MAGE-3。与MAGE-1和MAGE-3密切相关的基因MAGE-2和MAGE-4分别在30%和33%的肿瘤中表达。MAGE表达在肿瘤晚期更为常见：61%的浸润性肿瘤（分期>或=T2）至少四种基因之一的表达呈阳性，而只有28%的浅表性肿瘤（Ta期和T1期）表达这些基因。
