Doyle W J, Skoner D P, Seroky J T, Fireman P, Gwaltney J M
Department of Otolaryngology, Children's Hospital of Pittsburgh, PA.
J Allergy Clin Immunol. 1994 Feb;93(2):534-42. doi: 10.1016/0091-6749(94)90364-6.
To determine whether a viral upper respiratory tract infection can alter the responsiveness of the nasal mucosa, paired intranasal histamine and cold air challenge sessions were performed before and after (8 to 13 days) experimental rhinovirus infection in 18 nonallergic subjects and 20 subjects with seasonal allergic rhinitis. The nasal response to the challenges was measured as symptom scores for rhinorrhea and congestion, counts for sneezing, weight for expelled secretions, and inspiratory conductance for nasal patency. For both sessions, a greater response was observed in allergic subjects for sneezing, symptoms of rhinorrhea and congestion, secretion weights provoked by histamine challenge, and secretion weights provoked by cold air challenge when compared with the nonallergic subjects. A comparison of the responses to the paired challenge sessions showed greater responses for sneezing, secretion weight and rhinorrhea to histamine and for secretion weight to cold air challenges performed after rhinovirus infection. No differences were observed between allergic and nonallergic subjects with respect to the degree of enhanced responsiveness secondary to viral infection. These results document an increased responsiveness of the nose to these stimuli during the postsymptomatic period of a rhinovirus infection in both allergic and nonallergic subjects.
为了确定病毒性上呼吸道感染是否会改变鼻黏膜的反应性，在18名非过敏性受试者和20名季节性过敏性鼻炎受试者中，于实验性鼻病毒感染前及感染后（8至13天）进行了配对的鼻内组胺和冷空气激发试验。通过测量流涕和鼻塞的症状评分、打喷嚏次数、排出分泌物的重量以及鼻通畅度的吸气传导率来评估鼻腔对激发试验的反应。在两次试验中，与非过敏性受试者相比，过敏性受试者在打喷嚏、流涕和鼻塞症状、组胺激发试验引起的分泌物重量以及冷空气激发试验引起的分泌物重量方面均表现出更强的反应。对配对激发试验的反应进行比较发现，鼻病毒感染后，在打喷嚏、分泌物重量和流涕方面，对组胺激发试验的反应更强，在分泌物重量方面，对冷空气激发试验的反应更强。在病毒感染继发的反应性增强程度方面，过敏性和非过敏性受试者之间未观察到差异。这些结果表明，在鼻病毒感染的症状后期，过敏性和非过敏性受试者的鼻子对这些刺激的反应性均增强。
