挥发性麻醉剂恩氟烷、异氟烷和氟烷对犬心肌梗死模型心室延迟激活的影响。

Effects of volatile anesthetics, enflurane, isoflurane, and halothane on ventricular delayed activation in a canine myocardial infarction model.

作者信息

Imamura S, Hashimoto H, Ikeda K, Nakashima M

机构信息

Department of Pharmacology, Hamamatsu University School of Medicine, Japan.

出版信息

J Electrocardiol. 1994 Jan;27(1):41-8. doi: 10.1016/s0022-0736(05)80109-8.

DOI:10.1016/s0022-0736(05)80109-8

PMID:8120477

Abstract

The authors examined the effects of volatile anesthetics (enflurane, isoflurane, and halothane) on ventricular activation in a canine myocardial infarction model. Enflurane at 1 minimum aveolar concentration further delayed or blocked delayed activation in the infarcted zones with only slight effects on activation of the normal zones. Halothane showed similar and comparable effects on ventricular activation to those of enflurane. Although isoflurane also showed similar effects, they were of a lesser extent. Enflurane and halothane, but not isoflurane, inhibited ventricular stimulation-induced arrhythmias. Thus, enflurane and halothane produced marked depression of delayed activation in myocardial infarction, which may affect, that is, inhibit or provoke, ventricular arrhythmias in myocardial infarction.

摘要

作者在犬心肌梗死模型中研究了挥发性麻醉剂（恩氟烷、异氟烷和氟烷）对心室激活的影响。恩氟烷在1个最低肺泡浓度时进一步延迟或阻断梗死区域的延迟激活，而对正常区域的激活仅有轻微影响。氟烷对心室激活的影响与恩氟烷相似且相当。虽然异氟烷也表现出类似的作用，但程度较轻。恩氟烷和氟烷可抑制心室刺激诱发的心律失常，而异氟烷则不能。因此，恩氟烷和氟烷可使心肌梗死中的延迟激活显著受抑，这可能会影响，即抑制或诱发心肌梗死中的室性心律失常。