Murie N, Goasguen J, Almange C, Huguenin A
Nouv Presse Med. 1975 Nov 1;4(37):2635-8.
The authors used the stimulation of TSH test by intravenous injection of TRH in 93 patients. They obtained a negative or weak response in thyrotoxicosis, toxic adenomas, and Means syndrome, and a normal response with non-extinctive hot nodules. The response was positive and high in primary hypothyroidism. The results are sometimes paradoxal in hypothalamo-pituitary pathology even after hypophysectomy: a delayed and elevated response is in favour of a pituitary reserve of non-utilised TSH. In non-functional goitres and thyroiditis, the sometimes positive responses obtained are an indication for substitutive and depressive therapy.
作者对93例患者采用静脉注射促甲状腺激素释放激素（TRH）刺激促甲状腺激素（TSH）试验。他们发现，甲状腺毒症、毒性腺瘤和梅恩斯综合征患者的反应为阴性或弱阳性，非消退性热结节患者反应正常。原发性甲状腺功能减退患者的反应为阳性且反应强烈。即使在垂体切除术后，下丘脑 - 垂体病变患者的结果有时也会自相矛盾：反应延迟且增强提示垂体存在未利用的TSH储备。在非功能性甲状腺肿和甲状腺炎患者中，有时获得的阳性反应是替代和抑制治疗的指征。
