潜在的抗肿瘤剂。XXII. 咪唑并[2,1-b]噻唑金刚烷基硫脲的合成及细胞毒性活性

Potential antitumor agents. XXII. Synthesis and cytotoxic activity of imidazo [2,1-b]thiazole adamantylthioureas.

作者信息

Andreani A, Rambaldi M, Locatelli A, Bossa R, Fraccari A, Galatulas I

机构信息

Università di Bologna, Dipartimento di Scienze Farmaceutiche, Via Belmeloro 6, Italy.

出版信息

J Pharm Belg. 1993 Sep-Oct;48(5):378-82.

Abstract

A series of imidazo[2,1-b]thiazole adamantylthioureas (3a-f) was synthesized by reaction of the methylsulfanylethylamines 2a-f (prepared in turn from the hydroxymethylimidazo[2,1-b]thiazoles 1a-f and cysteamine) with 1-adamantylisothiocyanate. 1-Adamant-1-yl-3-[2-(6-chloro-2,3- dihydroimidazo[2,1-b]thiazol-5-ylmethylsulfanyl)ethyl] thiourea (3d) was significantly active.

摘要

通过甲硫烷基乙胺2a - f（依次由羟甲基咪唑并[2,1 - b]噻唑1a - f和半胱胺制备）与1 - 金刚烷基异硫氰酸酯反应，合成了一系列咪唑并[2,1 - b]噻唑金刚烷基硫脲（3a - f）。1 - 金刚烷 - 1 - 基 - 3 - [2 - (6 - 氯 - 2,3 - 二氢咪唑并[2,1 - b]噻唑 - 5 - 基甲基硫烷基)乙基]硫脲（3d）具有显著活性。

相似文献

1

Potential antitumor agents. XXII. Synthesis and cytotoxic activity of imidazo [2,1-b]thiazole adamantylthioureas.潜在的抗肿瘤剂。XXII. 咪唑并[2,1-b]噻唑金刚烷基硫脲的合成及细胞毒性活性

J Pharm Belg. 1993 Sep-Oct;48(5):378-82.

2

[Compounds with potential antitumor activity. VI. Esters of 6-substituted 5-hydroxymethylimidazo(2,1-b)thiazoles].[具有潜在抗肿瘤活性的化合物。VI. 6-取代的5-羟甲基咪唑并(2,1-b)噻唑的酯类]

Farmaco Sci. 1980 Nov;35(11):896-901.

3

Potential antitumor agents. 37. Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from the new heterocyclic system thiazolo[2',3':2,3]imidazo[4,5-c]quinoline.潜在的抗肿瘤剂。37. 咪唑并[2,1-b]噻唑和新杂环体系噻唑并[2',3':2,3]咪唑并[4,5-c]喹啉胍腙的合成及抗肿瘤活性

J Med Chem. 2005 Apr 21;48(8):3085-9. doi: 10.1021/jm040888s.

4

Potential antitumor agents. 24. Synthesis and pharmacological behavior of imidazo[2,1-b]thiazole guanylhydrazones bearing at least one chlorine.

J Med Chem. 1996 Jul 5;39(14):2852-5. doi: 10.1021/jm9509307.

5

New antitumor imidazo[2,1-b]thiazole guanylhydrazones and analogues.新型抗肿瘤咪唑并[2,1-b]噻唑胍腙及其类似物。

J Med Chem. 2008 Feb 28;51(4):809-16. doi: 10.1021/jm701246g. Epub 2008 Feb 6.

6

Novel thiazolidine-2,4-dione-4-thiosemicarbazone and 4-[(3,4-diaryl-3H-thiazol-2-yl)azo]thiazolidin-2-one derivatives: synthesis and evaluation for antimicrobial and anticancer properties.新型噻唑烷-2,4-二酮-4-硫代半卡巴腙和4-[(3,4-二芳基-3H-噻唑-2-基)偶氮]噻唑烷-2-酮衍生物：抗菌和抗癌性能的合成与评价

Farmaco Sci. 1985 Jan;40(1):49-57.

7

Synthesis and antitumor activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones.取代的3-(5-咪唑并[2,1-b]噻唑基亚甲基)-2-吲哚酮的合成及其抗肿瘤活性

Anticancer Drug Des. 2001 Apr-Jun;16(2-3):167-74.

8

Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives.新型咪唑并[2,1-b]噻唑衍生物的合成及初步细胞毒性评价

Eur J Med Chem. 2007 Mar;42(3):320-6. doi: 10.1016/j.ejmech.2006.10.012. Epub 2006 Dec 4.

9

Antitumor activity of new substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and study of their effect on the cell cycle.新型取代的3-(5-咪唑并[2,1-b]噻唑基亚甲基)-2-吲哚酮的抗肿瘤活性及其对细胞周期影响的研究

J Med Chem. 2005 Aug 25;48(17):5604-7. doi: 10.1021/jm050353e.

10

[Compounds with presumable antitumor activity. II. 2-Substituted 3-(2-thiazolyl) and 3-[2-(1,3,4,-thiadizolyl)]-4-thiazolidinones].[具有潜在抗肿瘤活性的化合物。II. 2-取代的3-(2-噻唑基)和3-[2-(1,3,4-噻二唑基)]-4-噻唑烷酮]

Farmaco Sci. 1984 Jun;39(6):505-13.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验