Massry S G, Llach F, Singer F R, Kurokawa K, Coburn J W
Proc Eur Dial Transplant Assoc. 1975;11:451-6.
Patients with mild renal failure have elevated blood levels of PTH, and acute hypocalcaemia in these patients produced a greater increment in blood PTH than in normal subjects. There was also a delay in the recovery from hypocalcaemia in patients with mild renal failure as compared to normal subjects. The data are consistent with the presence of skeletal resistance to the calcaemic action endogenous PTH in patients with mild renal failure. This abnormality is probably responsible for the hypocalcaemia of patients with renal failure and to the state of secondary hyperparathyroidism in such patients.
轻度肾衰竭患者的甲状旁腺激素（PTH）血液水平升高，与正常受试者相比，这些患者的急性低钙血症导致血液中PTH的增加幅度更大。与正常受试者相比，轻度肾衰竭患者从低钙血症中恢复的时间也有所延迟。这些数据与轻度肾衰竭患者骨骼对内源性PTH的钙调节作用存在抵抗一致。这种异常可能是肾衰竭患者低钙血症以及此类患者继发性甲状旁腺功能亢进状态的原因。
