下丘脑去传入对大鼠脑内促甲状腺激素释放激素水平的影响。
Effect of hypothalamic deafferentation on thyrotropin-releasing hormone levels in rat brain.
作者信息
Brownstein M J, Utiger R D, Palkovits M, Kizer J S
出版信息
Proc Natl Acad Sci U S A. 1975 Oct;72(10):4177-9. doi: 10.1073/pnas.72.10.4177.
The medial basal hypothalamus was isolated from the remainder of the brain of the rat using a Halász knife. Ten to 14 days after the surgical procedure the concentration of thyrotropin-releasing hormone within the island of hypothalamic tissue was 76% lower than in tissue from sham-operated control rats. Thus, much of the thyrotropin-releasing hormone that is normally present in the medial basal hypothalamus may be synthesized by cells outside of this region. There were no reductions in hormone levels in regions outside of the hypothalamic island after the surgical procedure. Extrahypothalamic thyrotropin-releasing hormone does not appear to be produced by hypothalamic neurosecretory cells.
使用哈拉斯刀将大鼠脑的内侧基底下丘脑与脑的其余部分分离。手术操作10至14天后，下丘脑组织岛内促甲状腺激素释放激素的浓度比假手术对照大鼠组织中的低76%。因此，内侧基底下丘脑中正常存在的许多促甲状腺激素释放激素可能是由该区域以外的细胞合成的。手术后下丘脑岛以外区域的激素水平没有降低。下丘脑外促甲状腺激素释放激素似乎不是由下丘脑神经分泌细胞产生的。
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