大鼠视网膜中促甲状腺激素释放激素样物质：因环境光照引起的变化。
Thyrotropin-releasing hormone-like material in the rat retina: changes due to environmental lighting.
作者信息
Schaeffer J M, Brownstein M J, Axelrod J
出版信息
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3579-81. doi: 10.1073/pnas.74.8.3579.
Abstract
Material reacting with an antibody to thyrotropin-releasing hormone (TRH) has been found to be present in the rat retina. The compound present in the retina cochromatographed with authentic TRH and most of its activity was lost when incubated with pyroglutamate aminopeptidase (L-pyroglutamyl-peptide hydrolase, EC 3.4.11.8), an enzyme that degrades TRH. The TRH-like activity in the rat retina was low during the night and high during the day. There was a 4-hr lag period after the lights were turned on before peak TRH levels were attained. A decrease in TRH was seen after 2 hr of darkness and the level of TRH was lowest after 4 hr of darkness. Retinal TRH is elevated by environmental lighting regardless of the time of the day. These findings suggest that TRH may be involved in retinal photorecptive mechanisms.
摘要
已发现大鼠视网膜中存在与促甲状腺激素释放激素（TRH）抗体发生反应的物质。视网膜中存在的这种化合物与 authentic TRH 共色谱，并且当与焦谷氨酸氨肽酶（L-焦谷氨酰肽水解酶，EC 3.4.11.8）一起孵育时，其大部分活性丧失，该酶可降解 TRH。大鼠视网膜中的 TRH 样活性在夜间较低，白天较高。开灯后有 4 小时的延迟期，之后才达到 TRH 峰值水平。黑暗 2 小时后可见 TRH 减少，黑暗 4 小时后 TRH 水平最低。无论一天中的什么时间，环境光照都会使视网膜 TRH 升高。这些发现表明，TRH 可能参与视网膜光感受机制。
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