人类寿命的演变以及控制衰老速率的遗传复杂性。
Evolution of human longevity and the genetic complexity governing aging rate.
作者信息
Cutler R G
出版信息
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4664-8. doi: 10.1073/pnas.72.11.4664.
Abstract
Genetic complexity of processes governing the aging rate of man was estimated by determining the maximum rate lifespan has evolved along the hominid ancestral-descendant sequence. Maximum lifespan potential was found to have increased approximately 2-fold over the past 3 million years, reaching a maximum rate of increase of 14 years per 100,000 years about 100,000 years ago. It is estimated that about 0.6% of the total functional genes have received substitutions leading to one or more adaptive amino acid changes during this 100,000-year time-period. This suggests that aging is not the result of an expression of a large number of independently acting processes. Instead, primary aging processes appear to exist where only a few genetic changes are necessary to decrease uniformly the aging rate of many different physiological functions.
摘要
通过确定人类沿着原始人祖先-后代序列进化的最大寿命速率，估算了控制人类衰老速率过程的遗传复杂性。发现最大寿命潜力在过去300万年中增加了约2倍，在约10万年前达到了每10万年增加14年的最大速率。据估计，在这10万年的时间段内，约0.6%的总功能基因发生了替代，导致一个或多个适应性氨基酸变化。这表明衰老不是大量独立作用过程表达的结果。相反，似乎存在主要的衰老过程，在这些过程中，只需要少数基因变化就能均匀地降低许多不同生理功能的衰老速率。
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本文引用的文献
1
The inevitability of growing old.衰老的必然性。
J Chronic Dis. 1967 Jul;20(7):475-86. doi: 10.1016/0021-9681(67)90079-3.
2
The moulding of senescence by natural selection.自然选择对衰老的塑造。
J Theor Biol. 1966 Sep;12(1):12-45. doi: 10.1016/0022-5193(66)90184-6.
3
Non-Darwinian evolution.非达尔文式进化
Science. 1969 May 16;164(3881):788-98. doi: 10.1126/science.164.3881.788.
4
A reconstruction of the femur of Australopithecus africanus.南方古猿非洲种股骨的重建。
Am J Phys Anthropol. 1970 Jan;32(1):33-40. doi: 10.1002/ajpa.1330320105.
5
On the rate of molecular evolution.论分子进化速率。
J Mol Evol. 1971;1(1):1-17. doi: 10.1007/BF01659390.
6
Survivorship in gracile and robust australopithecines: a demographic comparison and a proposed birth model.纤细型和粗壮型南方古猿的生存情况：人口统计学比较及提出的生育模型。
Am J Phys Anthropol. 1971 May;34(3):417-26. doi: 10.1002/ajpa.1330340311.
7
The casts of fossil hominid brains.化石人类大脑的铸模。
Sci Am. 1974 Jul;231(1):106-15. doi: 10.1038/scientificamerican0774-106.
8
Posterior tooth size, body size, and diet in South African gracile Australopithecines.南非纤细南方古猿的后牙大小、身体大小与饮食
Am J Phys Anthropol. 1973 Nov;39(3):375-93. doi: 10.1002/ajpa.1330390306.
9
Redundancy of information content in the genome of mammalian species as a protective mechanism determining aging rate.哺乳动物基因组中信息内容的冗余作为一种决定衰老速率的保护机制。
Mech Ageing Dev. 1973;2(6):381-408. doi: 10.1016/0047-6374(73)90032-8.
10
Organization, transcription, and regulation in the animal genome.动物基因组中的组织、转录与调控。
Q Rev Biol. 1973 Dec;48(4):565-613. doi: 10.1086/407817.
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