衰老及其与果蝇成虫盘细胞生长和分化的关系：对生长限制条件的发育反应。
Aging and its relation to cell growth and differentiation in Drosophila imaginal discs: developmental response to growth restricting conditions.
作者信息
Schweizer P, Bodenstein D
出版信息
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4674-8. doi: 10.1073/pnas.72.11.4674.
Abstract
The development of Drosophila organ discs can be arrested by culturing them in adult male flies. These aged discs lose some of their differentiation competence and form incomplete imaginal structures. The more advanced the aging, the greater the loss of competence. Discs made to differentiate prematurely show deficiencies similar to aged discs. The age-induced defects can be repaired in a larval milieu. Special hormonal conditions, but not cell multiplication, are apparently involved in the recovery process.
摘要
通过在成年雄蝇体内培养，果蝇器官盘的发育会受到抑制。这些老化的器官盘失去了一些分化能力，形成不完全的成虫结构。老化程度越高，能力丧失越严重。过早分化的器官盘表现出与老化器官盘相似的缺陷。年龄诱导的缺陷在幼虫环境中可以修复。恢复过程显然涉及特殊的激素条件，而非细胞增殖。
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