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关于铅暴露的问题能否预测铅水平升高?

Do questions about lead exposure predict elevated lead levels?

作者信息

Tejeda D M, Wyatt D D, Rostek B R, Solomon W B

机构信息

Department of Pediatrics, California Pacific Medical Center, San Francisco 94118.

出版信息

Pediatrics. 1994 Feb;93(2):192-4.

PMID:8121730
Abstract

OBJECTIVE

To assess the usefulness of the lead poisoning questionnaire developed by the Centers for Disease Control and Prevention as a screening tool for elevated lead levels.

METHODS

This descriptive study used a five-question questionnaire at our hospital-based general pediatric clinic and in two local private practices. We obtained venous lead levels from 485 children aged 9 months to 6 years who were brought for health supervision visits. The questionnaire was completed by a primary caretaker of 330 patients (68%). Contingency tables were used to compare lead levels with the responses on the questionnaire.

RESULTS

Lead levels of > or = 10 micrograms/dL were found in 23 (7%) of 330 who completed the questionnaire. Caretakers of children with elevated lead levels were more likely to answer yes to questions about chipping paint and home remodeling than those whose children had levels < 10 (P = .0001). These questions had sensitivities for detecting elevated lead levels of 70% and 74% with negative predictive values of 97% and 98%, respectively. Questions about known contacts with lead poisoning and job or industrial exposure to lead each had sensitivities of < 10%. The Centers for Disease Control and Prevention's definition of high risk for lead poisoning (one or more positive responses) was nearly 90% sensitive for detecting elevated lead levels with a negative predictive value of 99%.

CONCLUSION

This risk assessment questionnaire is an effective screening method for elevated lead levels in our population. Questions about the home environment were more sensitive indicators of elevated lead levels than other standard high-risk questions.

摘要

目的

评估美国疾病控制与预防中心编制的铅中毒调查问卷作为铅水平升高筛查工具的效用。

方法

这项描述性研究在我院的普通儿科诊所及两家当地私人诊所使用了一份包含五个问题的问卷。我们获取了485名9个月至6岁前来进行健康监测访视儿童的静脉血铅水平。问卷由330名患者(68%)的主要照料者填写。列联表用于比较铅水平与问卷回答情况。

结果

在完成问卷的330人中,有23人(7%)的血铅水平≥10微克/分升。血铅水平升高儿童的照料者比血铅水平<10的儿童的照料者更有可能对有关油漆剥落和房屋翻新的问题回答“是”(P = 0.0001)。这些问题检测血铅水平升高的敏感度分别为70%和74%,阴性预测值分别为97%和98%。关于已知铅中毒接触史以及工作或工业铅暴露的问题,敏感度均<10%。美国疾病控制与预防中心对铅中毒高风险的定义(一个或多个肯定回答)检测血铅水平升高的敏感度近90%,阴性预测值为99%。

结论

这份风险评估问卷是我们人群中血铅水平升高的有效筛查方法。关于家庭环境的问题比其他标准高风险问题更能敏感地指示血铅水平升高。

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