Effect of single infusion of fat emulsion on plasma lipid.

Plasma triglyceride and nonesterified fatty acid levels as well as the fatty acid composition of plasma triglycerides were determined after the infusion of 10 per cent Intralipid. Fat emulsion from 2 to 4 grams per kilogram of body weight given at 0.4 gram per kilogram of body weight given at 0.4 gram per kilogram of body weight per hour was removed from the blood circulation rapidly. Four grams of fat per kilogram of body weight given intravenously at 0.8 gram per kilogram of body weight per hour was not even removed from circulation three hours after the infusion and had considerable effect on the plasma lipid. On the other hand, the simultaneous infusion of 0.5 gram of fat and 8 U.S.P. units of heparin per kilogram of body weight per hour released more lipoprotein lipase than the fat emulsion alone. This data indicate that fat emulsion should be given approximately at 0.4 gram per kilogram of body weight per hour or less with simultaneous infusion of 8 U.S.P. units of heparin per kilogram of body weight per hour.