Wollen A L, Sandvei R, Skare A, Justesen N P
Institute of Anatomy and Cell Biology, University of Bergen, Norway.
Acta Obstet Gynecol Scand. 1994 Mar;73(3):195-9. doi: 10.3109/00016349409023438.
The localization and concentration of copper in cryostat sections of human fallopian tubes from women using an intrauterine contraceptive device (IUCD) and controls was determined by light microscopic- and atomic absorption spectrophotometric techniques. The copper was visually accumulated in the epithelium and the copper concentration in the tubal tissue was increased in the IUCD user group. We also measured the concentration of copper and ceruloplasmin in serum, but there was no statistical difference between the two groups studied. Our results indicate that the IUCD has effects beyond the uterine cavity. The accumulation of copper may be associated with earlier observations of the morphological changes and infiltration of inflammatory cells observed in the fallopian tube in IUCD users.
采用光学显微镜和原子吸收分光光度技术，测定了使用宫内节育器（IUCD）的女性及对照组女性输卵管低温恒温器切片中铜的定位和浓度。在IUCD使用者组中，可见铜在上皮细胞中蓄积，输卵管组织中的铜浓度升高。我们还测量了血清中铜和铜蓝蛋白的浓度，但研究的两组之间没有统计学差异。我们的结果表明，IUCD的作用超出子宫腔。铜的蓄积可能与IUCD使用者输卵管中形态学变化及炎性细胞浸润的早期观察结果有关。
