Whittaker J A, Davies P, Khurshid M
Acta Haematol. 1975;54(6):350-7. doi: 10.1159/000208098.
The Y chromosome was missing from the cells of aspirated bone marrow in 2 patients with chronic granulocytic leukaemia (CGL). in both cases, blast cell transformation occurred within 17 months of presentation. Their short course is in contrast to the hypothesis that absence of the Y chromosome in CGL is compatible with long survival.
2例慢性粒细胞白血病(CGL)患者抽吸的骨髓细胞中Y染色体缺失。在这两例病例中,原始细胞转化均发生在就诊后的17个月内。它们病程较短,这与CGL中Y染色体缺失与长期生存相容的假说形成了对比。