• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Proteolysis of human native and oxidised alpha 1-proteinase inhibitor by matrilysin and stromelysin.

作者信息

Zhang Z, Winyard P G, Chidwick K, Murphy G, Wardell M, Carrell R W, Blake D R

机构信息

Inflammation Research Group, London Hospital Medical College, University of London, UK.

出版信息

Biochim Biophys Acta. 1994 Mar 2;1199(2):224-8. doi: 10.1016/0304-4165(94)90119-8.

DOI:10.1016/0304-4165(94)90119-8
PMID:8123672
Abstract

Matrilysin is shown to rapidly inactivate alpha 1PI, an inhibitor of elastase, by cleaving the Pro357-Met358 peptide bond of its reactive centre. The rate of inactivation of alpha 1PI by matrilysin is four times higher than stromelysin. Matrilysin cleaves oxidised alpha 1PI at the Phe352-Leu353 bond, whilst stromelysin cleaves oxidised alpha 1PI at the Met358-Ser359 bond. We conclude that matrilysin is a potent serpinase which could play a role in inflammatory tissue damage by proteolytically inactivating alpha 1PI.

摘要

相似文献

1
Proteolysis of human native and oxidised alpha 1-proteinase inhibitor by matrilysin and stromelysin.
Biochim Biophys Acta. 1994 Mar 2;1199(2):224-8. doi: 10.1016/0304-4165(94)90119-8.
2
Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1-antitrypsin.在α1-抗胰蛋白酶的蛋白水解失活过程中，基质溶素比其他基质金属蛋白酶更有效。
Biochem Biophys Res Commun. 1994 Oct 28;204(2):613-20. doi: 10.1006/bbrc.1994.2503.
3
Proteolytic inactivation of human alpha 1 antitrypsin by human stromelysin.人基质溶解素对人α1抗胰蛋白酶的蛋白水解失活作用
FEBS Lett. 1991 Feb 11;279(1):91-4. doi: 10.1016/0014-5793(91)80258-5.
4
Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases.氧化激活的人中性粒细胞金属蛋白酶对α1-蛋白酶抑制剂和α1-抗糜蛋白酶的蛋白水解失活作用。
J Biol Chem. 1992 Mar 5;267(7):5005-12.
5
Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin).基质金属蛋白酶-1（组织胶原酶）、-2（72 kDa明胶酶/IV型胶原酶）和-3（基质溶解素）对α1-蛋白酶抑制剂、α1-抗糜蛋白酶及抗凝血酶III的失活作用的动力学及生理相关性
J Biol Chem. 1991 Aug 25;266(24):15810-6.
6
Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3.人基质溶解素-3对乳腺癌细胞衍生丝氨酸蛋白酶抑制剂的水解失活作用
J Biol Chem. 1994 Oct 14;269(41):25849-55.
7
Oxidative inactivation of alpha 1-proteinase inhibitor by alveolar macrophages from healthy smokers requires the presence of myeloperoxidase.健康吸烟者的肺泡巨噬细胞对α1-蛋白酶抑制剂的氧化失活需要髓过氧化物酶的存在。
Am J Respir Cell Mol Biol. 1991 Nov;5(5):437-44. doi: 10.1165/ajrcmb/5.5.437.
8
Understanding the P1' specificity of the matrix metalloproteinases: effect of S1' pocket mutations in matrilysin and stromelysin-1.了解基质金属蛋白酶的P1'特异性：基质溶素和基质溶解素-1中S1'口袋突变的影响。
Biochemistry. 1996 Aug 6;35(31):10103-9. doi: 10.1021/bi9601969.
9
Contribution of the C-terminal domain of metalloproteinases to binding by tissue inhibitor of metalloproteinases. C-terminal truncated stromelysin and matrilysin exhibit equally compromised binding affinities as compared to full-length stromelysin.金属蛋白酶C末端结构域对金属蛋白酶组织抑制剂结合的贡献。与全长基质溶素相比，C末端截短的基质溶素和基质溶解素表现出同样受损的结合亲和力。
J Biol Chem. 1994 Apr 29;269(17):12692-7.
10
Inhibition of neutrophil elastase by alpha-1-proteinase inhibitor oxidized by activated neutrophils.被活化中性粒细胞氧化的α-1-蛋白酶抑制剂对中性粒细胞弹性蛋白酶的抑制作用。
Am Rev Respir Dis. 1989 Mar;139(3):783-90. doi: 10.1164/ajrccm/139.3.783.

引用本文的文献

1
Multiplex quantification of C-terminal alpha-1-antitrypsin peptides provides a novel approach for characterizing systemic inflammation.多指标定量检测 C 端α-1 抗胰蛋白酶肽为系统炎症的特征分析提供了一种新方法。
Sci Rep. 2022 Mar 9;12(1):3844. doi: 10.1038/s41598-022-07752-w.
2
Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation.发现通过增强上皮屏障形成来促进组织修复的抗炎生理肽。
Sci Adv. 2021 Nov 19;7(47):eabj6895. doi: 10.1126/sciadv.abj6895. Epub 2021 Nov 17.
3
The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions.
α1-抗胰蛋白酶对中性粒细胞功能的多方面影响。
Front Pharmacol. 2018 Apr 17;9:341. doi: 10.3389/fphar.2018.00341. eCollection 2018.
4
The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung.丝氨酸蛋白酶和抗蛋白酶在囊性纤维化肺部中的作用
Mediators Inflamm. 2015;2015:293053. doi: 10.1155/2015/293053. Epub 2015 Jun 21.
5
Identification of Potential Glycoprotein Biomarkers in Estrogen Receptor Positive (ER+) and Negative (ER-) Human Breast Cancer Tissues by LC-LTQ/FT-ICR Mass Spectrometry.通过液相色谱-线性离子阱/傅里叶变换离子回旋共振质谱法鉴定雌激素受体阳性（ER+）和阴性（ER-）人乳腺癌组织中的潜在糖蛋白生物标志物
J Cancer. 2012;3:269-84. doi: 10.7150/jca.4592. Epub 2012 Jun 21.
6
Streptomyces erythraeus trypsin inactivates α1-antitrypsin.红色链霉菌胰蛋白酶使α1-抗胰蛋白酶失活。
FEBS Lett. 2011 Dec 15;585(24):3898-902. doi: 10.1016/j.febslet.2011.11.015. Epub 2011 Nov 21.
7
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.中性粒细胞弹性蛋白酶、蛋白酶 3 和组织蛋白酶 G 作为人类疾病的治疗靶点。
Pharmacol Rev. 2010 Dec;62(4):726-59. doi: 10.1124/pr.110.002733.
8
Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection.急性相蛋白完整和蛋白水解片段的升高构成了 HIV-1 感染中最早的全身性抗病毒反应。
PLoS Pathog. 2010 May 6;6(5):e1000893. doi: 10.1371/journal.ppat.1000893.
9
Antiproteases as therapeutics to target inflammation in cystic fibrosis.抗蛋白酶作为治疗囊性纤维化炎症的药物。
Open Respir Med J. 2010 Mar 30;4:20-31. doi: 10.2174/1874306401004020020.
10
Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase.细胞糖基磷脂酰肌醇连接膜型 6 基质金属蛋白酶的生化特性分析。
J Biol Chem. 2010 May 21;285(21):16076-86. doi: 10.1074/jbc.M110.107094. Epub 2010 Mar 22.