Labia R, Kazmierczak A, Philippon A, Le Goffic F, Faye J C, Goldstein F W, Acar J F
Ann Microbiol (Paris). 1975 May-Jun;126A(4):449-59.
This report discusses the differences in enzymes of two populations of P. aeruginosa, one sensitive and the other resistant to carbenicillin, which were strains isolated from four patients with chronic urinary infections. These sensitive and resistant strains biosynthetize only one beta-lactamase which appears to be a cephalosporinase of the class Id of Richmond and Sykes (1973). In the four cases the bacterial resistance to carbenicillin does not involve a new beta-lactamase and is due to other factors.
本报告讨论了铜绿假单胞菌两个菌群中酶的差异,一个菌群对羧苄青霉素敏感,另一个菌群耐药,这些菌株是从四名慢性尿路感染患者中分离出来的。这些敏感菌株和耐药菌株仅生物合成一种β-内酰胺酶,该酶似乎是里士满和赛克斯(1973年)分类中的1d类头孢菌素酶。在这四个病例中,细菌对羧苄青霉素的耐药性并不涉及新的β-内酰胺酶,而是由其他因素引起的。