Babovic S, Shin M S, Angel M F, Im M J, Vander Kolk C A, Manson P N
Division of Plastic, Reconstructive and Maxillofacial Surgery, Johns Hopkins University School of Medicine, Baltimore.
Br J Plast Surg. 1994 Jan;47(1):15-9. doi: 10.1016/0007-1226(94)90111-2.
The effects of diabetes mellitus (DM) on skin flap tolerance to 3 h of secondary venous ischaemia were evaluated. Epigastric island flaps were elevated 3, 6 and 12 weeks after induction of DM in rats. In the non-diabetic control groups, the flap survival was 85% in the 3-week group, 72% in the 6-week, and 78% in the 12-week. In untreated DM groups, the flap survival significantly decreased to 40% in the 3-week group, 25% in the 6-week, and 17% in the 12-week (P < 0.05 in all groups). Flap survival in the DM/insulin group decreased to 31% in the 3-week group. Effects of insulin therapy, however, were observed in later stages of DM: 71% and 62% survival in the 6- and 12-week group, respectively. Significant linear correlations between enzymatic responses and the flap survival were found. The results suggest that DM is detrimental to flap tolerance and is associated with the lack of metabolic responses to secondary ischaemia.
评估了糖尿病（DM）对皮瓣耐受3小时继发性静脉缺血的影响。在大鼠诱导糖尿病后3、6和12周掀起腹壁岛状皮瓣。在非糖尿病对照组中，3周组皮瓣存活率为85%，6周组为72%，12周组为78%。在未经治疗的糖尿病组中，3周组皮瓣存活率显著降至40%，6周组为25%，12周组为17%（所有组P<0.05）。糖尿病/胰岛素组3周组皮瓣存活率降至31%。然而，胰岛素治疗的效果在糖尿病后期才观察到：6周组和12周组的存活率分别为71%和62%。发现酶反应与皮瓣存活率之间存在显著的线性相关性。结果表明，糖尿病对皮瓣耐受性有害，且与对继发性缺血缺乏代谢反应有关。
