大鼠胃动力调节中迷走神经核与门静脉区之间葡萄糖信号的相互作用

Interaction of glucose signals between the nucleus of the vagus nerve and the portal vein area in the regulation of gastric motility in rats.

作者信息

Sakaguchi T, Aono T, Ohtake M, Sandoh N

机构信息

Department of Physiology, Niigata University School of Medicine, Japan.

出版信息

Brain Res Bull. 1994;33(4):469-71. doi: 10.1016/0361-9230(94)90292-5.

DOI:10.1016/0361-9230(94)90292-5

PMID:8124586

Abstract

Intragastric pressures were examined after glucose injection into the nucleus of the vagus nerve (X) of the medulla oblongata or into the portal vein (PV) or both in bilaterally adrenalectomized rats. Ten mM glucose (500 nl) injected into the X or into the PV (25 microliters) decreased gastric pressure associated with insulin-hypoglycemia. Simultaneous injection of glucose into the X and PV produced a reduction in gastric pressure in an additive manner. In addition, a significant fall in gastric pressure was seen when an ineffective concentration of glucose was injected into the X and PV simultaneously. The results suggest that the X and PV signals interact with each other to inhibit gastric motility.

摘要

在双侧肾上腺切除的大鼠中，向延髓迷走神经核（X）或门静脉（PV）或两者注射葡萄糖后，检测胃内压。向X或PV注射10 mM葡萄糖（500 nl或25微升）可降低与胰岛素性低血糖相关的胃内压。同时向X和PV注射葡萄糖可使胃内压以相加的方式降低。此外，当向X和PV同时注射无效浓度的葡萄糖时，胃内压也出现显著下降。结果表明，X和PV信号相互作用以抑制胃蠕动。