Joffe R T, Sokolov S T
Mood Disorders Program, Clarke Institute of Psychiatry, Toronto, Ontario, Canada.
Crit Rev Neurobiol. 1994;8(1-2):45-63.
Clinical thyroid disorders are frequently associated with psychiatric symptomatology, thus supporting a role for thyroid hormones in the biological basis of psychiatric disorders, particularly mood disorders. Despite extensive literature documenting various abnormalities of thyroid function tests in primary major depression, the role of thyroid hormones in the pathophysiology of affective disorders remains to be clarified. In this review, we describe the various abnormalities of thyroid hormone levels reported in primary affective illness. We also review the competing hypothesis to explain the abnormalities of thyroid function observed. Although neither model can fully explain the role of thyroid hormones in depressive illness, they provide working hypotheses for further study. Additional research is required to clarify the regulation of thyroid hormones by mature brain and the role of these hormones in the biological basis of affective illness.
临床甲状腺疾病常与精神症状相关，从而支持甲状腺激素在精神疾病尤其是情绪障碍生物学基础中发挥作用。尽管有大量文献记载原发性重度抑郁症患者甲状腺功能检查存在各种异常，但甲状腺激素在情感障碍病理生理学中的作用仍有待阐明。在本综述中，我们描述了原发性情感疾病中报告的甲状腺激素水平的各种异常情况。我们还回顾了用于解释所观察到的甲状腺功能异常的相互竞争的假说。尽管这两种模型都不能完全解释甲状腺激素在抑郁症中的作用，但它们为进一步研究提供了可行的假说。需要更多研究来阐明成熟大脑对甲状腺激素的调节以及这些激素在情感疾病生物学基础中的作用。
