Golden R N, Potter W Z
Psychiatr Clin North Am. 1986 Jun;9(2):313-27.
Depressed patients demonstrate dysregulation in multiple neurochemical and neuroendocrine systems. The observed abnormalities are often subtle, involving "inefficiencies" in stress-responsive systems. Norepinephrine, acetylcholine, the hypothalamic-pituitary-adrenal axis, and the hypothalamic-pituitary-thyroid axis are among the major biochemical and hormonal sites of dysregulation in depression.
抑郁症患者表现出多种神经化学和神经内分泌系统的失调。观察到的异常通常很细微，涉及应激反应系统中的“效率低下”。去甲肾上腺素、乙酰胆碱、下丘脑 - 垂体 - 肾上腺轴和下丘脑 - 垂体 - 甲状腺轴是抑郁症中失调的主要生化和激素位点。
