Kondo K, Takahashi M, Ohmizu H, Matsumoto M, Taguchi I, Iwasaki T
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd., Osaka, Japan.
Chem Pharm Bull (Tokyo). 1994 Jan;42(1):62-6. doi: 10.1248/cpb.42.62.
2,2'-Disubstituted biphenyl compounds (1-15) were synthesized by using the Ullmann coupling reaction as a key step. The suppressive effect of these compounds against CCl4-induced liver injuries in mice was evaluated. An unsymmetrical biphenyl (14f) exhibited the most potent activity. The structure-activity relationship is discussed.
以乌尔曼偶联反应为关键步骤合成了2,2'-二取代联苯化合物（1-15）。评估了这些化合物对小鼠四氯化碳诱导的肝损伤的抑制作用。一种不对称联苯（14f）表现出最强的活性。讨论了构效关系。
