Benke T
Department of Neurology, University Clinic Innsbruck, Austria.
Cortex. 1993 Dec;29(4):715-25. doi: 10.1016/s0010-9452(13)80292-4.
Apraxia was tested in 12 DAT patients with mild to moderate dementia using two assessment procedures: conceptual tasks requiring object use and pantomime knowledge, and tasks based on the imitation of meaningless oral and hand movements. Both object use and pantomime performance were markedly impaired in the DAT group; imitation of hand postures, hand movements and multiple oral movements was also defective while single oral movements could be well imitated. Error analysis revealed several underlying deficits: on conceptual tasks, deficits in object and action knowledge and poor action planning were frequent, whereas impaired recall and coordination of spatial and temporal movement features were found on imitation tasks. A correlation analysis between both types of apraxia showed low and nonsignificant results. These and previous observations suggest that motor control is organized by two functionally separate systems: a conceptual system for purposeful and symbolic motor acts, and a system controlling sensorimotor and spatiotemporal movement features. Both systems may be subject to early damage in Alzheimer's disease.
采用两种评估程序，对12名患有轻度至中度痴呆的多巴胺转运体（DAT）患者进行失用症测试：一种是需要物体使用和手势知识的概念任务，另一种是基于模仿无意义的口腔和手部动作的任务。DAT组的物体使用和手势表现均明显受损；手部姿势、手部动作和多个口腔动作的模仿也存在缺陷，而单个口腔动作则可以很好地模仿。错误分析揭示了几个潜在缺陷：在概念任务中，物体和动作知识的缺陷以及动作计划不佳很常见，而在模仿任务中则发现空间和时间运动特征的回忆和协调受损。两种类型失用症之间的相关性分析结果较低且无统计学意义。这些以及之前的观察结果表明，运动控制由两个功能上独立的系统组织：一个用于有目的和象征性运动行为的概念系统，以及一个控制感觉运动和时空运动特征的系统。这两个系统在阿尔茨海默病中可能都会早期受损。
